Manesh B. Shah Genome Analysis And Systems Modeling Group Building 5700 Oak Ridge National Laboratory P.O. Box 2008, MS 6164 Oak Ridge, TN 37831-6164 Email: shahmb@ornl.gov Phone: (865)-241-1963 Fax:     (865)-576-5332

Senior Research Associate
Genome Analysis and Systems Modeling Group
Life Sciences Division

WORK EXPERIENCE

• Senior Research Associate, Genome Analysis and Systems Modeling Group,
  Life Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN, 1992-present.
• Senior Computer Programmer, Biology Division
  Oak Ridge National Laboratory, Oak Ridge, TN, 1988-1992.
• Teacing Assistant, Computer Science Department
  University of Tennessee, Knoxville, TN, 1986-1988.

EDUCATION

• M.S., Computer Science Dept.,   University of Tennessee, Knoxville
• B.Tech., Institute of Technology,  Banaras Hindu University, Varanasi, India

RESEARCH INTERESTS

My principal interest is in the software development of scalable, robust, high throughput systems for bioinformatics analysis tools deployment. Another major focus is the development of highly intuitive web and Java user interfaces for access to these analysis systems. I am the principal architect (and led the software implementation team) of the systems described below.

• Web Software Architecture for Bioinformatics Analysis Systems:

  Genome Analysis Pipeline
  Protein Strucure Prediction Pipeline
  Protein Structure Prediction Automated Servers
  
  

• Client-Server Architecture and GUIs for Bioinformatics Analysis Systems:

  XGRAIL: X Windows based online, interactive client-server system for DNA sequence analysis
  Grail
  GrailEXP
  
  

• 3-d graphics, tomographic image reconstruction and modeling of chromosome structures:

  Development of software tools for interactive visualization and manipulation of tomographic data, incorporating surface and volume rendering techniques.

PUBLICATIONS

• M. Shah, S. Passovets, D. Kim, K. Ellrott, L. Wang, I. Vokler, P. Locascio, D. Xu, Ying Xu, A Computational Pipeline for Protein Structure Prediction and Analysis at Genome Scale, Proceedings of IEEE Conference on Bioinformatics and Biotechnology, in press, 2003.
• D. Xu, P. Dam, D. Kim, M. Shah, E. Uberbacher, and Ying Xu, Characterization of Protein Structrue and Function at Genome-scale using a Computational Prediction Pipeline, accepted to appear in Genetic Engineering: Principles and Methods , Vol 32, Jane Setlow (Ed.), Plenum Press, 2003.
• Uberbacher, E. C., Ying Xu, M. B. Shah, V. Olman, M. Parang, R. J. Mural, "An Editing Environment for DNA Sequence Analysis and Annotation", Proceedings of The Pacific Symposium on Biocomputing, 217 - 227, 1998.
• Ying Xu, Richard J. Mural, J. R. Einstein, Manesh Shah, and E. C. Uberbacher, "GRAIL: A Multi-Agent Neural Network System for Gene Identification", Proceedings of The IEEE, 84 (10), 1544 - 1552, 1996.